Electrospun Scaffolds in Periodontal Wound Healing

Periodontitis is a set of inflammatory conditions affecting the tissues surrounding teeth predominantly sustained by bacterial infections. The aim work was design and development scaffolds based on biopolymers to be inserted in periodontal pocket restore tissue integrity treat Nanofibrous were prepared means electrospinning. Gelatin considered as base component associated low high molecular weight chitosans alginate. characterized chemico–physical properties (morphology, solid state-FTIR differential scanning calorimetry (DSC)-surface zeta potential contact angle), mechanical properties. Moreover, preclinical (cytocompatibility, fibroblast osteoblast adhesion proliferation antimicrobial properties) assessed. All cylindrical smooth nanofibers preserved their nanofibrous structure upon hydration independently composition. They possessed degree hydrophilicity negative potentials physiological environment, suitable surface enhance cell inhibit bacteria attachment. scaffold gelatin chitosan proved effective vitro support both fibroblasts osteoblasts impair Streptococcus mutans Aggregatibacter actinomycetemcomitans, pathogens involved periodontitis.